P-chlorophenylalanine increases glutamate receptor 1 transcription in rat amygdala
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چکیده
منابع مشابه
Synaptic expression of glutamate receptor after encoding of fear memory in the rat amygdala.
Fear conditioning has been ascribed to presynaptic mechanisms, particularly presynaptic facilitation of transmission at thalamo- and cortico-amygdala synapses. Here, by labeling surface receptors with biotin or using membrane fractionation approaches, we report that fear conditioning resulted in an increase in surface expression of GluR1 subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleprop...
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The brain damage which occurs in untreated phenylketonuria probably results from the high plasma phenylalanine concentration prevailing in this condition, as treatment with a low-phenylalanine diet mitigates the situation. The actual cause of the brain damage is not known, but investigations have been carried out with high phenylalanine loads to simulate phenylketonuria and so elucidate the nat...
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Local injections of the neurotoxin SP-saporin into the basolateral amygdala (BLA) are reported to specifically lesion substance P receptor immunoreactive (SPR-IR) interneurons, and to reduce anxiety related behavior. Hence, this technique might provide a means to study how defined interneuron populations regulate neuronal activity in the BLA. However, what interneuron subgroups in the BLA might...
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ژورنال
عنوان ژورنال: NeuroReport
سال: 2011
ISSN: 0959-4965
DOI: 10.1097/wnr.0b013e32834ae2a1